Article
The LPA gene C93T polymorphism influences plasma lipoprotein(a) levels and is independently associated with susceptibility to peripheral arterial disease.
Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2008
Catalano Mariella, Cortelazzo Adriano, Yilmaz Yusuf, Perilli Edoardo, Carzaniga Gianni, Emanuele Enzo
Abstract excerpt
BACKGROUND: Plasma lipoprotein(a) [Lp(a)] levels are mainly genetically determined. The C93T polymorphism is a naturally occurring variant of the LPA gene that may influence Lp(a) concentration. The role of Lp(a) in the pathogenesis of peripheral arterial disease (PAD) has not been firmly established. METHODS: A total of 299 patients with PAD and 312 PAD-free control subjects were investigated. Genotyping of the...
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