Article
A common mutation in the lipoprotein lipase gene promoter, -93T/G, is associated with lower plasma triglyceride levels and increased promoter activity in vitro.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1997
Hall S, Chu G, Miller G, Cruickshank K, Cooper J A, Humphries S E, Talmud P J
Abstract excerpt
Single-strand conformational polymorphism analysis of the lipoprotein lipase promoter identified a T-->G transition at position -93. The frequency in healthy white men was 3.4% (n = 1575). There was an 83% allelic association between -93T-->G and Asp9-->Asn (D9N); all N9 mutations occurred on a -93G allele, but not all -93G mutations occurred on an N9 allele. It was thus possible to assess the effect on plasma...
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