Article
B-cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindred.
British journal of haematology - 1 Dec 2007
Abbasi Fatima, Longo Nancy S, Lipsky Peter E, Raveche Elizabeth, Schleinitz Therese A, Stetler-Stevenson Maryalice, Caporaso Neil, Marti Gerald
Abstract excerpt
Monoclonal B cell lymphocytosis (MBL) was detected in four unaffected first-degree relatives (FDR) in a familial chronic lymphocytic leukaemia (CLL) kindred. The proband remains untreated and two male siblings have died. The four unaffected siblings have been followed for a five-year period. All four FDR developed a kappa(+)CD5(+) MBL detected by flow cytometry. Poymerase chain reaction (PCR) for IGHV...
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