Article
B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia.
Cytometry. Part B, Clinical cytometry - 1 Mar 2003
Marti Gerald E, Carter Patricia, Abbasi Fatima, Washington Glennelle C, Jain Nisha, Zenger Vincent E, Ishibe Naoko, Goldin Lynn, Fontaine Laura, Weissman Nancy, Sgambati Maria, Fauget Guy, Bertin Pablo, Vogt Robert F, Slade Barbara, Noguchi Philip D, Stetler-Stevenson M A, Caporaso Neil
Abstract excerpt
BACKGROUND: Among all hematologic malignancies, B-cell chronic lymphocytic leukemia (BCLL) has the highest familial clustering (three- to sevenfold increase), strongly suggesting a genetic component to its etiology. Familial BCLL can be used as a model to study the early pathogenesis of this disease. METHODS: We examined nine kindreds from the National Cancer Institute's Familial BCLL Registry, consisting of 19...
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