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Article

Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells.

Journal of cellular physiology - 1 Apr 2008

Mancino Mario, Strizzi Luigi, Wechselberger Christian, Watanabe Kazuhide, Gonzales Monica, Hamada Shin, Normanno Nicola, Salomon David S, Bianco Caterina

Abstract excerpt

Human Cripto-1 (CR-1) is a cell membrane protein that is overexpressed in several different types of human carcinomas. In the present study we investigated the mechanisms that regulate the expression of CR-1 gene in cancer cells. We cloned a 2,481 bp 5'-flanking region of the human CR-1 gene into a luciferase reporter vector and transfected NTERA-2 human embryonal carcinoma cells and LS174-T colon cancer cells to...

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PMID: 17941089
DOI: 10.1002/jcp.21301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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