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Article

Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter.

The Journal of biological chemistry - 21 Nov 2003

Coulet Florence, Nadaud Sophie, Agrapart Monique, Soubrier Florent

Abstract excerpt

The human endothelial nitric-oxide synthase gene (heNOS) is constitutively expressed in endothelial cells, and its expression is induced under hypoxia. The goal of this study was to search for regulatory elements of the endothelial nitric-oxide synthase (eNOS) gene responsive to hypoxia. Levels of eNOS mRNA, measured by real time reverse transcriptase-PCR analysis, were increased, and heNOS promoter activity was...

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Identifiers

PMID: 12963737
DOI: 10.1074/jbc.M305420200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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