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Article

A negative regulatory element within the proximal promoter region of the rat ornithine decarboxylase gene.

Molecular carcinogenesis - 1 Dec 2000

Zhao B, Kumar A P, Butler A P

Abstract excerpt

A putative Ets site with a core of GGAA located at nt -88 to -85 of the rat ornithine decarboxylase (ODC) gene was characterized by site-directed mutagenesis and transient expression assays. Mutation of this site, when in pODClux2m, which contains a cluster of four Sp1-binding sites, resulted in a 2.6-fold increase in basal promoter activity in untreated cells, whereas the ratio of activity in...

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PMID: 11170259
DOI: 10.1002/1098-2744(200012)29:4<212::aid-mc1003>3.0.co;2-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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