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Article

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

Cancer cell - 1 Oct 2007

Berns Katrien, Horlings Hugo M, Hennessy Bryan T, Madiredjo Mandy, Hijmans E Marielle, Beelen Karin, Linn Sabine C, Gonzalez-Angulo Ana Maria, Stemke-Hale Katherine, Hauptmann Michael, Beijersbergen Roderick L, Mills Gordon B, van de Vijver Marc J, Bernards René

Abstract excerpt

A large-scale RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants of PIK3CA (activator of the same pathway and frequently mutated in breast cancer) also conferred resistance to trastuzumab in cell culture. In a cohort of 55 breast cancer patients, activation of the PI3K pathway, as judged by the...

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Share to Antibodies, Monoclonal, Humanized
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Patient Selection

Share to Phosphatidylinositol 3-Kinases

Share to PTEN Phosphohydrolase

Share to Receptor, ErbB-2

Share to Transduction, Genetic

Share to Trastuzumab

Source

Identifiers

PMID: 17936563
DOI: 10.1016/j.ccr.2007.08.030

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.PMID 17936563Read ↗

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