Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expressional analysis of anti-apoptotic phospho-BAD protein and mutational analysis of pro-apoptotic BAD gene in hepatocellular carcinomas.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Sept 2006

Yoo N J, Lee J W, Jeong E G, Soung Y H, Nam S W, Lee J Y, Lee S H

Abstract excerpt

BACKGROUND: It has become clear that, together with proliferation, deregulation of apoptosis plays a pivotal role in tumourigenesis. BAD is a pro-apoptotic Bcl-2 family protein and regulates the intrinsic apoptosis pathway. Phosphorylation of BAD inhibits the apoptosis function of BAD. AIMS: To investigate whether alteration of the phospho-BAD protein and somatic mutation of BAD gene are characteristics of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-Associated Death Protein
Share to BH3 Interacting Domain Death Agonist Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Hepatocytes

Share to Immunohistochemistry

Share to Liver Neoplasms

Share to Phosphorylation

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 16807152
DOI: 10.1016/j.dld.2006.05.018

Genes

BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Expressional analysis of anti-apoptotic phospho-BAD protein and mutational analysis of pro-apoptotic BAD gene in hepatocellular carcinomas.PMID 16807152Read ↗

Immunohistochemical analysis of phospho-BAD protein and mutational analysis of BAD gene in gastric carcinomas.Semantic proximity Read ↗

Pro-apoptotic PUMA and anti-apoptotic phospho-BAD are highly expressed in colorectal carcinomas.Semantic proximity Read ↗

Expressional and mutational analysis of pro-apoptotic Bcl-2 member PUMA in hepatocellular carcinomas.Semantic proximity Read ↗

Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms.Semantic proximity Read ↗

Inactivating mutations of proapoptotic Bad gene in human colon cancers.Semantic proximity Read ↗

BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.Semantic proximity Read ↗

Immunohistochemical study of apoptotic marker p53 as a prognostic factor in breast cancer.Semantic proximity Read ↗

Mutation of BAD within the BH3 domain impairs its phosphorylation-mediated regulation.Semantic proximity Read ↗

The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3.Semantic proximity Read ↗

BAK overexpression mediates p53-independent apoptosis inducing effects on human gastric cancer cellsSemantic proximity Read ↗

Inactivating mutation of the pro-apoptotic gene BID in gastric cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.