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Article

Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.

Nature neuroscience - 1 Nov 2007

Lobo Mary Kay, Cui Yijun, Ostlund Sean B, Balleine Bernard W, Yang X William

Abstract excerpt

Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental...

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Identifiers

PMID: 17934457
DOI: 10.1038/nn1987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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