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Article

Pleiotropy and heterogeneity in the expression of bone strength-related phenotypes in extended pedigrees.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2007

Wang Xiaojing, Kammerer Candace M, Wheeler Victor W, Patrick Alan L, Bunker Clareann H, Zmuda Joseph M

Abstract excerpt

UNLABELLED: Genetic analysis in 3,535 relative pairs from extended multigenerational families of African heritage showed that volumetric BMD is a highly heritable polygenic trait that is under compartment-specific genetic regulation. The majority of the phenotypic variation in bone size and volumetric BMD also seems to be strongly influenced by distinct genes for each trait. INTRODUCTION: BMD and bone size...

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PMID: 17931101
DOI: 10.1359/jbmr.070718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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