Article
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.
Basic & clinical pharmacology & toxicology - 1 Jan 2008
Sinués Blanca, Fanlo Ana, Vicente Jorge, Mayayo-Sinués Esteban, Mayayo Esteban, Labarta Jose I, Ferrandez-Longás Angel
Abstract excerpt
A large number of metabolic alterations are increasingly being treated with growth hormone. Despite the fact that growth hormone is known to be the main regulator of several hepatic drug metabolizing enzymes in rodents, few studies deal with the effect of growth hormone on hepatic enzyme activities in human beings. The aim of this study was to determine the effects of growth hormone replacement therapy for 4...
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