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Article

Effect of the CYP2C8 genotype on the pharmacokinetics and pharmacodynamics of repaglinide.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2011

Tomalik-Scharte Dorota, Fuhr Uwe, Hellmich Martin, Frank Dorothee, Doroshyenko Oxana, Jetter Alexander, Stingl Julia C

Abstract excerpt

The pharmacokinetics of repaglinide shows pronounced interindividual variability, for which several reasons have been considered, including interactions with drugs inhibiting CYP2C8 and CYP2C8 genetic polymorphism. However, existing data on the role of genetic polymorphisms in repaglinide disposition are not fully consistent. We studied the effect of CYP2C8*3 on the pharmacokinetics and pharmacodynamics of...

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Identifiers

PMID: 21270106
DOI: 10.1124/dmd.110.036921

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