Article
Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer.
PloS one - 1 Jan 2017
Padala Chiranjeevi, Tupurani Mohini Aiyengar, Puranam Kaushik, Gantala Srilatha, Shyamala Nivas, Kondapalli Mrudula Spurthi, Gundapaneni Kishore Kumar, Mudigonda Saraswati, Galimudi Rajesh Kumar, Kupsal Keerthi, Nanchari Santoshi Rani, Chavan Uday, Chinta Sanjeeva Kumari, Mukta Srinivasulu, Satti Vishnupriya, Hanumanth Surekha Rani
Abstract excerpt
BACKGROUND: Extracellular matrix degradation by matrix metalloproteinases (MMPs) is an important mechanism involved in tumor invasion and metastasis. Genetic variations of MMPs have shown association with multiple cancers. The present study is focused to elucidate the association of MMP-1, 3 and 9 genetic variants with respect to epidemiological and clinicopathological variables by haplotype, LD, MDR, survival in...
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