Article
Interstitial collagenases as markers of tumor progression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2000
Brinckerhoff C E, Rutter J L, Benbow U
Abstract excerpt
Degradation of the extracellular matrix is the sine qua non of tumor invasion and metastasis. Most of this degradation is mediated by matrix metalloproteinases (MMPs), a family of enzymes that, collectively, degrades the extracellular matrix. Although the basement membrane-degrading enzymes, MMP-2 and MMP-9, have been given considerable attention for their roles in invasion and metastasis, the interstitial...
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