Article
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.
The EMBO journal - 1 Oct 1997
Vaziri H, West M D, Allsopp R C, Davison T S, Wu Y S, Arrowsmith C H, Poirier G G, Benchimol S
Abstract excerpt
Telomere loss has been proposed as a mechanism for counting cell divisions during aging in normal somatic cells. How such a mitotic clock initiates the intracellular signalling events that culminate in G1 cell cycle arrest and senescence to restrict the lifespan of normal human cells is not known...
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