Article
Single nucleotide polymorphisms and functional analysis of class II transactivator (CIITA) promoter IV in persistent HBV infection.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Nov 2007
Zhang Xuqing, Hong Xiaojun, Deng Guohong, Bai Xiujuan
Abstract excerpt
BACKGROUND/AIMS: CIITA plays a pivotal role in immune response, and the outcome of HBV infection is influenced by immune response. The aims of this study were to analyze the effect of CIITA promoter IV polymorphisms on its activity, and their association with persistent HBV infection. METHODS: The polymorphisms in promoter IV (C-1350T and G-944C) were analyzed by tetra-primer amplification refractory mutation...
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