Article
From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes.
Journal of molecular biology - 16 Nov 2007
Frank Bettina, Wenzel Silke C, Bode Helge B, Scharfe Maren, Blöcker Helmut, Müller Rolf
Abstract excerpt
The myxobacterial polyketide secondary metabolites aurafuron A and B were identified by genome mining in the myxobacterial strain Stigmatella aurantiaca DW4/3-1. The compounds contain an unusual furanone moiety and resemble metabolites isolated from soil-dwelling and marine actinobacteria, a fungus and mollusks. We describe here the cloning and functional analysis of the aurafuron biosynthetic gene cluster,...
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