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Article

Nrf2-mediated heme oxygenase-1 induction confers adaptive survival response to tetrahydropapaveroline-induced oxidative PC12 cell death.

Antioxidants & redox signaling - 1 Dec 2007

Park So-Hyun, Jang Jung-Hee, Li Mei-Hua, Na Hye-Kyung, Cha Young-Nam, Surh Young-Joon

Abstract excerpt

Tetrahydropapaveroline (THP), a dopaminergic isoquinoline neurotoxin, has been reported to contribute to neurodegeneration in parkinsonism. As THP bears two catechol moieties, it undergoes autooxidation or enzymatic oxidation to produce reactive oxygen species (ROS), which may contribute to the THP-induced cell death. Although ROS are cytotoxic, the initial accumulation of ROS may provoke a survival response. In...

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Identifiers

PMID: 17919066
DOI: 10.1089/ars.2007.1828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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