Article
The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2008
Costa-Mallen Paola, Checkoway Harvey, Zabeti Aram, Edenfield Michael J, Swanson Phillip D, Longstreth W T, Franklin Gary M, Smith-Weller Terri, Sadrzadeh Sayed M H
Abstract excerpt
Oxidative stress and iron have been widely implicated in the etiology of Parkinson's disease (PD). Hemoglobin is the richest source of iron in the body. The human Haptoglobin (Hp) protein is a plasma alpha-2 glycoprotein that removes free Hemoglobin from the circulation and tissues and is important in protection from oxidative stress, in immune system regulation, and angiogenesis. A common genetic polymorphism of...
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