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Article

Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain.

Journal of molecular modeling - 1 Dec 2007

Li Minyong, Wang Binghe

Abstract excerpt

Virulent H5N1 strains of influenza virus often harbor a D92E point mutation in the nonstructural protein NS1. This crucial mutation has been correlated with increased virulence and/or cytokine resistance, but the structural implications of such a change are still unclear. Furthermore, NS1 protein could also be a potential target for the development of novel antiviral agents against H5N1 strains. Therefore, a...

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Identifiers

PMID: 17917748
DOI: 10.1007/s00894-007-0245-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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