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Article

Impaired T-amplitude adaptation to heart rate characterizes I(Kr) inhibition in the congenital and acquired forms of the long QT syndrome.

Journal of cardiovascular electrophysiology - 1 Dec 2007

Couderc Jean-Philippe, Vaglio Martino, Xia Xiajuan, McNitt Scott, Wicker Pierre, Sarapa Nenad, Moss Arthur J, Zareba Wojciech

Abstract excerpt

INTRODUCTION: The QTc interval prolongation is not a perfect surrogate marker of the presence of an increased risk for arrhythmic events. In the search for alternative markers, we investigated the T-amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT syndrome (LQTS) and individuals with sotalol-induced QT prolongation. METHODS AND RESULTS: Our investigation is based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17916157
DOI: 10.1111/j.1540-8167.2007.00960.x

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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