Article
Gene-specific effect of beta-adrenergic blockade on corrected QT interval in the long QT syndrome.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc - 1 Jul 2013
Extramiana Fabrice, Maison-Blanche Pierre, Denjoy Isabelle, De Jode Patrick, Messali Anne, Labbé Jean-Philippe, Leenhardt Antoine
Abstract excerpt
BACKGROUND: In the long QT syndrome (LQTS) the effects of beta-blocker treatment on prevention of cardiac events differs according to the genotype. We aimed to assess the effect of beta-blocker treatment on QT/QTc duration in Type 1 LQTS (LQT1) and Type 2 LQTS (LQT2) patients. METHODS: 24-hour digital Holter ECG were recorded before and after beta-blocking therapy initiation in LQT1 (n = 30) and LQT2 patients (n...
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