Article
A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
Diabetes - 1 Feb 2010
Paterson Andrew D, Waggott Daryl, Boright Andrew P, Hosseini S Mohsen, Shen Enqing, Sylvestre Marie-Pierre, Wong Isidro, Bharaj Bhupinder, Cleary Patricia A, Lachin John M, Below Jennifer E, Nicolae Dan, Cox Nancy J, Canty Angelo J, Sun Lei, Bull Shelley B
Abstract excerpt
OBJECTIVE: Glycemia is a major risk factor for the development of long-term complications in type 1 diabetes; however, no specific genetic loci have been identified for glycemic control in individuals with type 1 diabetes. To identify such loci in type 1 diabetes, we analyzed longitudinal repeated measures of A1C from the Diabetes Control and Complications Trial. RESEARCH DESIGN AND METHODS: We performed a...
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