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Article

HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration.

Autophagy - 1 Jan 2000

Pandey Udai Bhan, Batlevi Yakup, Baehrecke Eric H, Taylor J Paul

Abstract excerpt

The two major intracellular catabolic pathways, the ubiquitin-proteasome system (UPS) and macroautophagy (autophagy), have each been implicated as playing roles in neurodegenerative proteinopathies. We have investigated the relationship between the UPS and autophagy using Drosophila models of neurodegenerative diseases. We identified histone deacetylase 6 (HDAC6) as a genetic modifier of polyglutamine-induced...

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Source

Identifiers

PMID: 17912024
DOI: 10.4161/auto.5050

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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