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Article

Circulating tumor DNA measurement provides reliable mutation detection in mice with human lung cancer xenografts.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2018

Wei Ling, Xie Li, Wang Xingwu, Ma Hongxin, Lv Liyan, Liu Lisheng, Song Xianrang

Abstract excerpt

Genotype-directed targeted therapy has become one of the standard treatment options for non-small cell lung cancer (NSCLC). There have been numerous limitations associated with mutation analysis of tissue samples. Consequently, mutational profile analysis of circulating cell-free DNA (cfDNA) by highly sensitive droplet digital PCR (ddPCR) assay has been developed. Possibly due to differences in cfDNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29497175
DOI: 10.1038/s41374-018-0041-8

Genes

ACTB
EGFR
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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