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Article

CMTM5 Exhibits Tumor Suppressor Activities and Is Frequently Silenced by Methylation in Carcinoma Cell Lines

1 Oct 2007

Abstract excerpt

PURPOSE: CMTM5 (CKLF-like MARVEL transmembrane domain containing member 5) is located at 14q11.2, a locus associated with multiple cancers. It has six RNA splicing variants with CMTM5-v1 as the major one. We explored its expression pattern in normal tissues and tumor cell lines, as well as its functions in carcinoma cells. EXPERIMENTAL DESIGN: We evaluated CMTM5 expression by semiquantitative reverse...

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PMID: 17908965
DOI: 10.1158/1078-0432.ccr-06-3082

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