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Article

Mutational analysis of VACM-1/cul5 exons in cancer cell lines.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jul 2011

Lewis Steven P, Willis Angelica N, Johnson Alyssa E, Resau James, Burnatowska-Hledin Maria A

Abstract excerpt

VACM-1, a cul-5 gene product, functions via an E3 ligase complex and when overexpressed, has an antiproliferative effect in many cell types. Overexpression of VACM-/cul5 cDNA mutated at the PKA-specific phosphorylation site at Ser730 reversed this phenotype. These effects are associated with the...

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PMID: 21635549
DOI: 10.1111/j.1600-0463.2011.02747.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21635549-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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