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Article

Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas.

Cancer research - 15 Mar 2016

Bouillez Audrey, Rajabi Hasan, Pitroda Sean, Jin Caining, Alam Maroof, Kharbanda Akriti, Tagde Ashujit, Wong Kwok-Kin, Kufe Donald

Abstract excerpt

Dysregulation of MYC expression is a hallmark of cancer, but the development of agents that target MYC has remained challenging. The oncogenic MUC1-C transmembrane protein is, like MYC, aberrantly expressed in diverse human cancers. The present studies demonstrate that MUC1-C induces MYC expression in KRAS mutant non-small cell lung cancer (NSCLC) cells, an effect that can be suppressed by targeting MUC1-C via...

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Source

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Identifiers

PMID: 26833129
DOI: 10.1158/0008-5472.CAN-15-1804
PMCID: PMC4794417

Genes

MYC
MUC1
KRAS
CDK4
CTNNB1
TCF4
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas.PMID 26833129Read ↗

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