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Article

MUC1-C drives MYC in multiple myeloma

24 Feb 2016

Abstract excerpt

Multiple myeloma (MM) cell lines and primary tumor cells are addicted to the MYC oncoprotein for survival. Little is known, however, about how MYC expression is upregulated in MM cells. The mucin 1 C-terminal subunit (MUC1-C) is an oncogenic transmembrane protein that is aberrantly expressed in MM cell lines and primary tumor samples. The present studies demonstrate that targeting MUC1-C with silencing by...

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PMID: 26907633
DOI: 10.1182/blood-2015-07-659151

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MUC1-C drives MYC in multiple myelomaPMID 26907633Read ↗

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