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Article

Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.

Antimicrobial agents and chemotherapy - 1 Dec 2007

Chen Chih-Ming, He Yupeng, Lu Liangjun, Lim Hock Ben, Tripathi Rakesh L, Middleton Tim, Hernandez Lisa E, Beno David W A, Long Michelle A, Kati Warren M, Bosse Todd D, Larson Daniel P, Wagner Rolf, Lanford Robert E, Kohlbrenner William E, Kempf Dale J, Pilot-Matias Tami J, Molla Akhteruzzaman

Abstract excerpt

A-837093 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase. It possesses nanomolar potencies in both enzymatic and replicon-based cell culture assays. In rats and dogs this compound demonstrated an oral pla...

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Identifiers

PMID: 17908950
DOI: 10.1128/AAC.00723-07
PMCID: PMC2167986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17908950-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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