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Article

Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).

Antimicrobial agents and chemotherapy - 1 Oct 2012

McPhee Fiona, Sheaffer Amy K, Friborg Jacques, Hernandez Dennis, Falk Paul, Zhai Guangzhi, Levine Steven, Chaniewski Susan, Yu Fei, Barry Diana, Chen Chaoqun, Lee Min S, Mosure Kathy, Sun Li-Qiang, Sinz Michael, Meanwell Nicholas A, Colonno Richard J, Knipe Jay, Scola Paul

Abstract excerpt

Asunaprevir (ASV; BMS-650032) is a hepatitis C virus (HCV) NS3 protease inhibitor that has demonstrated efficacy in patients chronically infected with HCV genotype 1 when combined with alfa interferon and/or the NS5A replication complex inhibitor daclatasvir. ASV competitively binds to the NS3/4A protease complex, with K(i) values of 0.4 and 0.24 nM against recombinant enzymes representing genotypes 1a (H77) and...

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Identifiers

PMID: 22869577
DOI: 10.1128/AAC.01186-12
PMCID: PMC3457370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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