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Article

New approaches to progeria.

Pediatrics - 1 Oct 2007

Kieran Mark W, Gordon Leslie, Kleinman Monica

Abstract excerpt

Progeria (Hutchinson-Gilford progeria syndrome) is a rare genetic disorder that offers considerable insight into the biology of premature aging. This review summarizes the clinical characteristics of this disease and the underlying mutation in the lamin A (LMNA) gene that results in this phenotype. Modifications in the processing of prelamin A through alterations in farnesylation are detailed, because this...

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Source

Identifiers

PMID: 17908771
DOI: 10.1542/peds.2007-1356

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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