Article
Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media.
Pediatrics - 1 Dec 2006
Patel Janak A, Nair Sangeeta, Revai Krystal, Grady James, Saeed Kokab, Matalon Reuben, Block Stan, Chonmaitree Tasnee
Abstract excerpt
OBJECTIVE: Susceptibility to otitis media results from complex interactions among genetic factors of the host, exposure to pathogens, and environmental influences. The objective of this study was to study the role of single-nucleotide polymorphisms of regulatory elements of proinflammatory cytokine genes tumor necrosis factor-alpha(-308), interleukin-1beta(+3953), and interleukin-6(-174), in susceptibility to...
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