Association between Cytokine Gene Polymorphisms and Risk for Upper Respiratory Tract Infection and Acute Otitis Media

Abstract excerpt

BACKGROUND: We previously reported an association between tumor necrosis factor alpha (TNFalpha)(-308)and interleukin (IL)-6(-174) polymorphisms and otitis susceptibility by history. Acute otitis media occurs most commonly as a complication of upper respiratory tract infection (URI); it is not clear why some children develop acute otitis media after URI and others do not. Our objective was to prospectively...

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