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Thymidine-Dependent <i>Staphylococcus aureus</i> Small-Colony Variants Are Associated with Extensive Alterations in Regulator and Virulence Gene Expression Profiles

22 Jun 2005

Abstract excerpt

Chronic airway infection is a hallmark of cystic fibrosis (CF) and many CF patients are infected persistently by Staphylococcus aureus. Thymidine-dependent trimethoprim-sulfamethoxazole (SXT)-resistant S. aureus small-colony variants (SCVs), often in combination with isogenic normal S. aureus phenotypes, are highly prevalent and persistent in airway secretions of CF patients due to long-term SXT therapy (B. Kahl,...

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PMID: 15972501
DOI: 10.1128/iai.73.7.4119-4126.2005

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