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Article

Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus.

Infection and immunity - 1 Apr 2008

Zander Johannes, Besier Silke, Saum Stephan H, Dehghani Faramarz, Loitsch Stefan, Brade Volker, Wichelhaus Thomas A

Abstract excerpt

Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients. The phenotypic appearance of S. aureus SCVs or normal-colony variants (NCVs) is postulated to be affected by the intracellular amount of dTMP. This hypothesis was proven by metabolic pathway assays revealing altered intracellular dTMP...

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Identifiers

PMID: 18160477
DOI: 10.1128/IAI.01075-07
PMCID: PMC2292857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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