Article
The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption.
The British journal of nutrition - 1 Apr 2008
Pérez-Martínez P, Adarraga-Cansino M D, Fernández de la Puebla R A, Blanco-Molina A, Delgado-Lista J, Marín C, Ordovás J M, López-Miranda J, Pérez-Jiménez F
Abstract excerpt
The objective of the study was to determine whether Plasminogen Activator Inhibitor Type 1 (PAI-1) -675 4G/5G polymorphism is associated with the response of functional plasma PAI-1 concentrations to changes in the amount and quality of dietary fat in healthy subjects. PAI-1 is the major inhibitor of fibrinolysis, and a lower level of fibrinolytic activity could be implicated in an increased risk of IHD....
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