Article
Cystic fibrosis Delta F508 heterozygotes, smoking, and reproduction: studies of 9141 individuals from a general population sample.
Genomics - 15 May 1998
Dahl M, Tybjaerg-Hansen A, Wittrup H H, Lange P, Nordestgaard B G
Abstract excerpt
Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested this hypot...
Topics
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Confounding Factors, Epidemiologic
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Denmark
- Family Characteristics
- Female
- Gene Frequency
- Genetic Carrier Screening
- Humans
- Male
- Middle Aged
- Mutation
- Reproduction
- Sex Factors