Article
Cystic fibrosis mutations in the Hutterite Brethren.
American journal of human genetics - 1 May 1990
Klinger K, Horn G T, Stanislovitis P, Schwartz R H, Fujiwara T M, Morgan K
Abstract excerpt
The presence or absence of the major cystic fibrosis (CF) mutation, delta F508, in the general patient population was determined by Kerem et al. using allele-specific oligonucleotides for the mutant and normal sequences in the polymerase chain reaction (PCR). delta F508 was identified by Riordan et al., and it is a 3-bp deletion of the phenylalanine codon at position 508. The Hutterite Brethren are an inbred...
Topics
- Base Sequence
- Canada
- Christianity
- Chromosome Deletion
- Cystic Fibrosis
- Genetic Linkage
- Haplotypes
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction