Article
Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction.
Journal of molecular medicine (Berlin, Germany) - 1 Jan 2008
Mangino Massimo, Braund Peter, Singh Ravi, Steeds Richard, Stevens Suzanne, Channer Kevin S, Samani Nilesh J
Abstract excerpt
The notion that coronary atherosclerosis and its most severe phenotype, myocardial infarction (MI), are chronic inflammatory diseases is supported by several lines of evidence. Interleukins (ILs) are important mediators and modulators of inflammation. Specific polymorphisms in the genes encoding subunits of IL-23 (IL-12B) and its receptor (IL-23R) have recently been consistently found to be associated with...
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