Article
Polymorphism of the 3'-untranslated region of interleukin-12 p40 gene is not associated with the presence or severity of coronary artery disease.
Circulation journal : official journal of the Japanese Circulation Society - 1 Jul 2005
Momiyama Yukihiko, Ohmori Reiko, Nagano Makoto, Kato Ryuichi, Taniguchi Hiroaki, Egashira Tohru, Nakamura Haruo, Ohsuzu Fumitaka
Abstract excerpt
BACKGROUND: Interleukin (IL)-12 is thought to play an important role in the development of atherosclerosis and recently, polymorphism of the 3'-untranslated region of the IL-12 p40 gene (A1188C) was reported to be associated with diabetes and multiple sclerosis. However, the association between this genetic polymorphism and coronary artery disease (CAD) has not been studied. METHODS AND RESULTS: The frequency of...
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