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Article

Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma.

Human molecular genetics - 15 Dec 2007

Hayden Patrick J, Tewari Prerna, Morris Derek W, Staines Anthony, Crowley Dominique, Nieters Alexandra, Becker Nikolaus, de Sanjosé Silvia, Foretova Lenka, Maynadié Marc, Cocco Pier Luigi, Boffetta Paolo, Brennan Paul, Chanock Stephen J, Browne Paul V, Lawler Mark

Abstract excerpt

Cytogenetic analysis in myeloma reveals marked chromosomal instability. Both widespread genomic alterations and evidence of aberrant class switch recombination, the physiological process that regulates maturation of the antibody response, implicate the DNA repair pathway in disease pathogenesis. We therefore assessed 27 SNPs in three genes (XRCC3, XRCC4 and XRCC5) central to DNA repair in patients with myeloma...

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Source

Identifiers

PMID: 17901044
DOI: 10.1093/hmg/ddm273

Genes

XRCC4
XRCC5
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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