Article
Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae.
Cancer science - 1 Dec 2007
Enomoto Shotaro, Maekita Takao, Tsukamoto Tetsuya, Nakajima Takeshi, Nakazawa Kazuyuki, Tatematsu Masae, Ichinose Masao, Ushijima Toshikazu
Abstract excerpt
The presence of high levels of aberrant DNA methylation in gastric mucosae correlates with risk of gastric cancer. Some gastric cancers are known to have methylation of multiple CpG islands (CGI), which is referred to as the CGI methylator phenotype (CIMP). In the present study, we aimed to clarify the possible association between the CIMP in cancers and high methylation levels in their background mucosae by...
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