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Article

Role of nsdA in negative regulation of antibiotic production and morphological differentiation in Streptomyces bingchengensis.

The Journal of antibiotics - 1 Jun 2009

Wang Xiang-Jing, Guo Suo-Lian, Guo Wan-Qian, Xi Di, Xiang Wen-Sheng

Abstract excerpt

To investigate the function of nsdA in Streptomyces bingchengensis, it was cloned and sequenced, which presented an 89.89% identity with that of S. coelicolor. The lambdaRED-mediated PCR-targeting technique was used to create nsdA replacement in the S. bingchengensis_226541 chromosome. The nsdA disruption mutant, BC29, was obtained, which produced more pigment and spores than did the ancestral strain. HPLC...

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Identifiers

PMID: 19444300
DOI: 10.1038/ja.2009.33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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