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Article

CpG island methylator phenotype predicts progression of malignant melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2009

Tanemura Atsushi, Terando Alicia M, Sim Myung-Shin, van Hoesel Anneke Q, de Maat Michiel F G, Morton Donald L, Hoon Dave S B

Abstract excerpt

PURPOSE: The CpG island methylator phenotype (CIMP) may be associated with development of malignancy through coordinated inactivation of tumor suppressor and tumor-related genes (TRG) and methylation of multiple noncoding, methylated-in-tumor (MINT) loci. These epigenetic changes create a distinct CIMP pattern that has been linked to recurrence and survival in gastrointestinal cancers. Because epigenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19223509
DOI: 10.1158/1078-0432.CCR-08-1361
PMCID: PMC2703821

Genes

SOCS1
TFPI2
WIF1
GATA4
TRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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