Airway epithelial cell cilia transcriptomic dysregulation is associated with the inflammatory phenotype in asthma

Abstract excerpt

Asthma is a heterogeneous disease in terms of phenotypes and endotypes, characterized by airway remodelling with epithelial dysfunction, including alterations of the mucociliary clearance.1 Previous studies identified motile cilia dysfunction in severe asthma.2, 3 Considering the importance of both motile and primary cilia in structural and functional epithelium integrity,4, 5 we investigated the associations...

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