Article
HSPC300 and its role in neuronal connectivity.
Neural development - 25 Sept 2007
Qurashi Abrar, Sahin H Bahar, Carrera Pilar, Gautreau Alexis, Schenck Annette, Giangrande Angela
Abstract excerpt
BACKGROUND: The WAVE/SCAR complex, consisting of CYFIP (PIR121 or Sra1), Kette (Nap1), Abi, SCAR (WAVE) and HSPC300, is known to regulate the actin nucleating Arp2/3 complex in a Rac1-dependent manner. While in vitro and in vivo studies have demonstrated that CYFIP, Kette, Abi and SCAR work as subunits of the complex, the role of the small protein HSPC300 remains unclear. RESULTS: In the present study, we...
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