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Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation

10 Feb 2020

Abstract excerpt

Memory and learning involve activity-driven expression of proteins and cytoskeletal reorganization at new synapses, requiring posttranscriptional regulation of localized mRNA a long distance from corresponding nuclei. A key factor expressed early in synapse formation is Msp300/Nesprin-1, which organizes actin filaments around the new synapse. How Msp300 expression is regulated during synaptic plasticity is poorly...

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PMID: 32040548
DOI: 10.1083/jcb.201903135

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