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Article

Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene.

Cancer science - 1 Nov 2007

Ziólkowska Iwona, Mosor Maria, Wierzbicka Malgorzata, Rydzanicz Malgorzata, Pernak-Schwarz Monika, Nowak Jerzy

Abstract excerpt

The high incidence of multiple primary tumors (MPT) is a significant problem in head and neck tumor treatment. Recent studies suggest that carriers of heterozygous mutations in the NBS1 gene have an increased risk of malignant tumor development. The aim of our research was to assess the frequency of NBS1 mutations in patients with larynx cancer only (LC) and with MPT. The MPT group consisted of patients with one...

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Identifiers

PMID: 17894553
DOI: 10.1111/j.1349-7006.2007.00594.x
PMCID: PMC11158328

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Related research

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Research trail→

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Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene.PMID 17894553Read ↗

Heterozygous carriers of the I171V mutation of the NBS1 gene have a significantly increased risk of solid malignant tumours.Semantic proximity Read ↗

Heterozygous germline mutations in NBS1 among Korean patients with high-risk breast cancer negative for BRCA1/2 mutation.Semantic proximity Read ↗

NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma.Semantic proximity Read ↗

Association of polymorphisms and haplotypes of the NBN gene with laryngeal cancer and multiple primary tumors of the head and neck.Semantic proximity Read ↗

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.Semantic proximity Read ↗

I171V germline mutation in the NBS1 gene significantly increases risk of breast cancer.Semantic proximity Read ↗

NBS1 variant I171V and breast cancer risk.Semantic proximity Read ↗

Hereditary p16-Leiden mutation in a patient with multiple head and neck tumors.Semantic proximity Read ↗

Increased cancer risk of heterozygotes with NBS1 germline mutations in Poland.Semantic proximity Read ↗

Mutational inactivation of the nijmegen breakage syndrome gene (NBS1) in glioblastomas is associated with multiple TP53 mutations.Semantic proximity Read ↗

Association of the heterozygous germline I171V mutation of the NBS1 gene with childhood acute lymphoblastic leukemiaSemantic proximity Read ↗

Functional <i>NBS1</i> polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinomaSemantic proximity Read ↗

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